VemoHerb Turkesterone

34.90

Supports the gain of lean muscle mass*
Contributes to faster exercise recovery*
Stimulates protein synthesis*
Powerful adaptogen properties for quicker adapting to stress and fatigue*
Antioxidant activity*

Description

EXPLOSIVE NATURAL POWER AND MUSCLE GROWTH!

Supports the gain of lean muscle mass*
Contributes to faster exercise recovery*
Stimulates protein synthesis*
Powerful adaptogen properties for quicker adapting to stress and fatigue*
Antioxidant activity*

VemoHerb® Turkesterone is the perfect herbal product you can use after training and be amazed from the spectacular results afterwards!

VemoHerb® Turkesterone:

  • Can be used as muscle building (anabolic) stimulant*
  • Promotes fast muscle growth and strength*
  • Assists the increase in carbohydrate and fatty acid metabolism*

VemoHerb® Turkesterone is based on dry extract from Ajuga turkestanica, standardized at minimum 10% turkesterone. Turkesterone is a phytoecdysteroid(5), found in plants. Ecdysteroids, as well as testosterone, have the ability to induce muscle growth in the human organism. However, they are preferred over testosterone, as no steroidal side effects, like gynecomastia or hair loss, are associated with their intake. [1]*

Turkesterone is considered to be the most efficient muscle building compound from the ecdysteroids group. [2,3] It stimulates the carbohydrate metabolism and protein synthesis, which results in increased muscle mass.[8]* At the same time, VemoHerb® Turkesterone helps the fat burning.[6]* Turkesterone helps increasing the glycogen reserves in the muscles, which are directly related to the energy production, in the form of ATP.* This allows you to perform more intense exercises without feeling muscle fatigue and tiredness.[7, 10, 12]*

This phytoecdysteroid has not only anabolic effects on the skeletal muscles making them bigger in size, but also reduces the muscle damage during intense workouts. Thus, athletes benefit from both building lean muscle mass, and recovering faster after each session, which allows for more intense and frequent workouts. That is why Turkesterone has been used by sportsmen and bodybuilders for improving physical performance, and for promoting vitality.[6]* VemoHerb Turkesterone is the perfect post-workout option, as it is an anabolic supplement, ideal for sports and exercises related to strength training, especially bodybuilding.[7]*

The pack contains

60 vegan capsules

Active substances in one capsule

500 mg Leuzea (aerial parts and fruits) Extract (Ajuga Turkestanica) (10%turkesterone)

Recommended daily dose

1-2 capsules daily – preferably prior training

Directions for use

Take between the meals or as directed on the label.

The product is a food supplement not a medical drug. The product is not a substitute for a varied diet. Do not exceed the recommended daily dose. It is not recommended for pregnant, nursing women and children!

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

References:

 

1.Gorelick-Feldman, J., Cohick, W. and Raskin, I., 2010. Ecdysteroids elicit a rapid Ca2+ flux leading to Akt activation and increased protein synthesis in skeletal muscle cells. Steroids, 75(10), pp.632-637.

Phytoecdysteroids, structurally similar to insect molting hormones, produce a range of effects in mammals, including increasing growth and physical performance. In skeletal muscle cells, phytoecdysteroids increase protein synthesis. In this study we show that in a mouse skeletal muscle cell line, C2C12, 20-hydroxyecdysone (20HE), a common phytoecdysteroid in both insects and plants, elicited a rapid elevation in intracellular calcium, followed by sustained Akt activation and increased protein synthesis. The effect was inhibited by a G-protein coupled receptor (GPCR) inhibitor, a phospholipase C (PLC) inhibitor, and a phosphoinositide kinase-3 (PI3K) inhibitor.

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2. Syrov, V., Hushbaktova, Z., Tashmuhamedova, M. and Saatov, Z., 1990. Experimental study on biological effects of phytoecdisteroids on mammals. European Journal of Pharmacology, 183(5), p.1753.

In experiments with white mice it has been established that phytoecdisteroides turkesteron, ecdisteron and 2-desoxy-alpha-ecdison in the dose of 5 mg on 1 kg of body mass stimulate the protein synthesis. Using the model of protein synthesis from mice liver it has been shown that the action of phytoecdisteroides is connected with the rise of poliribosome functional activity and rate increase of protein macromolecules formation. Preliminary administration of actinomycin D does not prevent the effect of protein synthesis stimulation. It has been concluded that the anabolic effect of phytoecdisteroides in mammals organism is connected not with induction of RNA synthesis but with the acceleration of translocation processes.

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3. Syrov, V., 2000. Comparative experimental investigation of the anabolic activity of phytoecdysteroids and steranabols. Pharmaceutical Chemistry Journal, 34(4), pp.193-197.

Many compounds originally isolated from plants have been used since ancient times as drugs. Among the classes of natural substances isolated relatively recently, of special interest are the so-called phytoecdysteroids. These compounds, structurally close or identical to the hormones of ecdysis (molting) and metamorphosis in insects, were found to be capable of activating protein biosynthesis in of mammals [1]. However, these drugs were not studied with respect to their possible anabolizing action upon the organism, especially in comparison with the steroidal anabolic preparations- derivatives of the male sex hormones, presently the most effective stimulants of the protein-anabolic processes.

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4. Gorelick-Feldman, J., Cohick, W. and Raskin, I., 2010. Ecdysteroids elicit a rapid Ca2+ flux leading to Akt activation and increased protein synthesis in skeletal muscle cells. Steroids, 75(10), pp.632-637.

Phytoecdysteroids, structurally similar to insect molting hormones, produce a range of effects in mammals, including increasing growth and physical performance. In skeletal muscle cells, phytoecdysteroids increase protein synthesis. In this study we show that in a mouse skeletal muscle cell line, C2C12, 20-hydroxyecdysone (20HE), a common phytoecdysteroid in both insects and plants, elicited a rapid elevation in intracellular calcium, followed by sustained Akt activation and increased protein synthesis. The effect was inhibited by a G-protein Coupled Receptor (GPCR) inhibitor, a phospholipase C (PLC) inhibitor, and a phosphoinositide kinase-3 (PI3K) inhibitor.

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5. Dinan, L., Bourne, P., Whiting, P., Tsitsekli, A., Saatov, Z., Dhadialla, T., Hormann, R., Lafont, R. and Coll, J., 2003. Synthesis and biological activities of turkesterone 11α-acyl derivatives. Journal of Insect Science, 3(1).

Turkesterone is a phytoecdysteroid possessing an 11α-hydroxyl group. It is an analogue of the insect steroid hormone 20-hydroxyecdysone. Previous ecdysteroid QSAR and molecular modelling studies predicted that the cavity of the ligand binding domain of the ecdysteroid receptor would possess space in the vicinity of C-11/C-12 of the ecdysteroid. We report the regioselective synthesis of a series of turkesterone 11α-acyl derivatives in order to explore this possibility. The structures of the analogues have been unambiguously determined by spectroscopic means (NMR and low-resolution mass spectrometry). Purity was verified by HPLC. Biological activities have been determined in Drosophila melanogaster BII cell-based bioassay for ecdysteroid agonists and in an in vitro radioligand-displacement assay using bacterially-expressed D. melanogaster EcR/USP receptor proteins. The 11α-acyl derivatives do retain a significant amount of biological activity relative to the parent ecdysteroid. Further, although activity initially drops with the extension of the acyl chain length (C2 to C4), it then increases (C6 to C10), before decreasing again (C14 and C20). The implications of these findings for the interaction of ecdysteroids with the ecdysteroid receptor and potential applications in the generation of affinity-labelled and fluorescently-tagged ecdysteroids are discussed.

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6. Das, N., Mishra, S., Bishayee, A., Ali, E. and Bishayee, A., 2021. The phytochemical, biological, and medicinal attributes of phytoecdysteroids: An updated review. Acta Pharmaceutica Sinica B, 11(7), pp.1740-1766.

The phytoecdysteroids (PEs) comprise a large group of biologically-active plant steroids, which have structures similar to those of insect-molting hormones. PEs are distributed in plants as secondary metabolites that offer protection against phytophagus (plant-eating) insects. When insects consume the plants containing these chemicals, they promptly molt and undergo metabolic destruction; the insects eventually die. Chemically, ecdysteroids are a group of polyhydroxylated ketosteroids that are structurally similar to androgens. The carbon skeleton of ecdysteroids is termed as cyclopentanoperhydro-phenanthrene with a β-side chain at carbon-17. The essential characteristics of ecdysteroids are a cis-(5β-H) junction of rings A and B, a 7-en-6-one chromophore, and a trans-(14α-OH) junction of rings C and D. Plants only synthesize PEs from mevalonic acid in the mevalonate pathway of the plant cell using acetyl-CoA as a precursor; the most common PE is 20-hydroxyecdysone. So far, over 400 PEs have been identified and reported, and a compilation of 166 PEs originating from 1998 has been previously reviewed. In the present review, we have summarized 212 new PEs reported between 1999 and 2019. We have also critically analyzed the biological, pharmacological, and medicinal properties of PEs to understand the full impact of these phytoconstituents in health and disease.

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7. Anabolic compounds in Ajuga turkestanica may potentially improve muscle growth and recovery.

Believed to carry bio-active compounds that resemble androgens in structure, Ajuga turkestanica could potentially impart such post-workout benefits as:

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8.Cheng, D., Yousef, G., Grace, M., Rogers, R., Gorelick-Feldman, J., Raskin, I. and Lila, M., 2008. In vitro production of metabolism-enhancing phytoecdysteroids from Ajuga turkestanica. Plant Cell, Tissue and Organ Culture, 93(1), pp.73-83.

In order to develop a sustainable source of metabolism-enhancing phytoecdysteroids, cell suspension and hairy root cultures were established from shoot cultures of wild-harvested Ajuga turkestanica, a medicinal plant indigenous to Uzbekistan. Precursors of phytoecdysteroids (acetate, mevalonic acid cholesterol) or methyl jasmonate (an elicitor) were added to subculture media to increase phytoecdysteroid accumulation. In cell suspension cultures, 20-hydroxyecdysone (20E) content increased 3- or 2-fold with the addition of 125 or 250μM methyl jasmonate, respectively, compared to unelicited cultures. Precursor addition, however, did not provoke phytoecdysteroid accumulation. In hairy root cultures, addition of sodium acetate, mevalonic acid, and methyl jasmonate, but not cholesterol, increased phytoecdysteroid content compared to unelicited cultures. Hairy root cultures treated with 150mgl−1 sodium acetate, or 15 or 150mgl−1 mevalonic acid, increased 20E content approximately 2-fold to 19.9, 20.4 or 21.7μgmg−1, respectively, compared to control (10.5μgmg−1). Older hairy root cultures, extracted after the seventh subculture cycle, also showed increases in 20E content (24.8μgmg−1), turkesterone (0.9μgmg−1) and cyasterone (8.1μgmg−1) compared to control cultures maintained for a shorter duration of four subculture cycles. Doses of 10 or 20μgml−1 hairy root extract increased protein synthesis by 25.7% or 31.1%, respectively, in a C2C12 mouse skeletal cell line. These results suggest that sustainable production of metabolically active phytoecdysteroid can be achieved through hairy root culture systems.

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9. Kokoska, L. and Janovska, D. – Chemistry and pharmacology of Rhaponticum carthamoides: A review. Phytochemistry (2009) 70: 842.

Rhaponticum carthamoides (Willd.) Iljin is a perennial herb, commonly known as a maral root or Russian leuzea, which has been used for centuries in eastern parts of Russia for its marked medicinal properties. This review based on 117 literary sources, with many of them being originally published in non-English languages (mainly in Russian), discusses the current knowledge of traditional uses, chemistry, biological effects and toxicity of this species. Several different classes of compounds were previously isolated from various parts of R. carthamoides of which the main groups are steroids, particularly ecdysteroids, and phenolics (flavonoids and phenolic acids) accompanied with polyacetylenes, sesquiterpene lactones, triterpenoid glycosides and terpenes (essential oil). A comprehensive account of the chemical constituents is given in this review (figures of 120 structures are shown). Various types of preparations, extracts and individual compounds derived from this species have been found to possess a broad spectrum of pharmacological effects on several organs such as the brain, blood, cardiovascular and nervous systems as well as on different biochemical processes and physiological functions including proteosynthesis, work capacity, reproduction, and sexual function. Moreover, the extracts and preparations from the plant, which are hopefully safe, exhibited various additional biological effects e.g. antioxidant, immunomodulatory, anticancerogenic, antimicrobial.

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10. Gorelick-Feldman, J., MacLean, D., Ilic, N., Poulev, A., Lila, M., Cheng, D. and Raskin, I. – Phytoecdysteroids Increase Protein Synthesis in Skeletal Muscle Cells. J Agric Food Chem. (2008) 56: 3532.

Phytoecdysteroids, which are structurally similar or identical to insect molting hormones, produce a range of effects in mammals, including increasing growth and physical performance. To study the mechanism of action of phytoecdysteroids in mammalian tissue, an in vitro cellular assay of protein synthesis was developed. In C2C12 murine myotubes and human primary myotubes, phytoecdysteroids increased protein synthesis by up to 20%. In vivo, ecdysteroids increased rat grip strength. Ecdysteroid-containing plant extracts produced similar results. The effect was inhibited by a phosphoinositide kinase-3 inhibitor, which suggests a PI3K-mediated mechanism.

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11. Chermnykh NS, Shimanovskiĭ NL, Shutko GV, Syrov VN – The action of methandrostenolone and ecdysterone on the physical endurance of animals and on protein metabolism in the skeletal muscles

The results of the comparative study on the myotropic activity of methandrostenolone and ecdysterone and their effects on physical endurance of animals suggested that ecdysterone possessing a wider spectrum of the anabolic action on the contractile proteins of the skeletal muscles exerts a more pronounced influence on physical endurance of animals without their preliminary training.

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12. Jonathan Gorelick-Feldman, David MacLean, Nebojsa Ilic, Alexander Poulev, Mary Ann Lila, Diana Cheng and Ilya Raskin – Phytoecdysteroids Increase Protein Synthesis in Skeletal Muscle Cells

Phytoecdysteroids, which are structurally similar or identical to insect molting hormones, produce a range of effects in mammals, including increasing growth and physical performance. To study the mechanism of action of phytoecdysteroids in mammalian tissue, an in vitro cellular assay of protein synthesis was developed. In C2C12 murine myotubes and human primary myotubes, phytoecdysteroids increased protein synthesis by up to 20%. In vivo, ecdysteroids increased rat grip strength. Ecdysteroid-containing plant extracts produced similar results. The effect was inhibited by a phosphoinositide kinase-3 inhibitor, which suggests a PI3K-mediated mechanism.

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Additional information

Weight 0.1 g

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