VemoHerb Tribulus Forte

19.90 

su_animate duration=”2″]Supports the normal adaptation of the body to the natural changes during menopause*[/su_animate] su_animate duration=”2″]Helps maintain the levels of cholesterol that are within the normal range*[/su_animate]

Description

A special extract of Bulgarian Tribulus terrestris

Supports the normal function of prostate and helps during menopausal period.*

How and Why It Works?

VemoHerb® Tribulus Forte supports the healthy prostate function and the other endocrine glands and supports the normal healthy attitude during menopause period.* [1 – 8]

In order for the main properties of protodioscin to be revealed, the rest of the saponins in this Bulgarian Tribulus terrestris extract have a very important role, helping the transformation of protodioscin to dehydroepiandrosterone (DHEA).* [9] It is believed that the latter slows down the aging processes.* During the normal steroidal synthesis in the organism, DHEA takes part in the conversion of cholesterol into sex hormones.*

The flavonoid glycosides support the resorption of fats and maintain the levels of cholesterol in the body which are already in normal range.* [10] The beneficial effect of VemoHerb® Tribulus Forte for maintaining normal cholesterol levels are linked to the role of the Bulgarian Tribulus terrestris extract in maintaining healthy fat levels in the blood and its positive influence on the immune system.* [11 – 13]

The combination of phytosterols, saponins and flavonoids supports:

the healthy prostate;* [3, 5, 7]

the menopausal women;* [3, 5, 6, 8]

the natural production of hormones;* [1, 2, 4, 5]

the immune system.* [12, 13]

The pack contains

60 capsules

Active substances in one capsule

200,0 mg dry extract from Bulgarian Tribulus terrestris with content of 50% furostanol saponins, determined as protodioscin and 25% flavonoids determined as apigenin

Recommended daily dose

Take 1-2 capsules 3 times a day

Directions for use

Take between the meals or as directed on the label.

The product is a food supplement not a medical drug. The product is not a substitute for a varied diet. Do not exceed the recommended daily dose. It is not recommended for pregnant, nursing women and children!

References:

1. Milanov, S., E. Maleeva, M. Tashkov. – Tribestan effect on the concentration of some hormones in the serum of healthy subjects (1981).

Tribestan effect has been studied on the serum concentration of hypophyseal hormones, of ACTH, STH, LH, FSH, adrenal hormone aldosterone and cortisol and sex hormones – testosterone and estradiol. The experiments have been carried out on 8 males and 8 females, aged 28 – 45 years of age. The product was perorally administered in a single dose of 250 mg, three times daily for 5 days. Serum samples were withdrawn at 8 a.m. and 12 a.m., prior to and post treatment. The product has been established not to change essentially the concentrations of adrenal hormones and of ACTH. The hypophyseal-gonadal axis however has significantly been affected in the females with predominantly increased concentration of FSH and estradiol and in the males – mainly of LH and the testosterone. The mechanism of that action is presumed to be complicated and realized both by direct effect on gonadal apparatus and by the tropic hormones. The probable established changes in the concentration of the hormones studied do not get out of the frames of the physiological limits. The lyophilized extract of Tribulus terrestris, introduced in veterinary practice as TB-68, has pronounced sex-stimulating function. The initial studies of this product showed that it stimulates the spermatogenesis of albino rats (Vankov S., et al., 1973) and enhanced the ovulation of female rats (Vankov S. et al. 1973). Zarkova S. (1976) has also established in rats an increased number of spermatogonia, spermatocytes as well as increase of neutral mucopolysaccharides in seminiferous tubules of the testes. Gendzhev Z. and S. Zarkova, in other experiments (1978) proved the increase of spermatic reserve in the epididymis of rats. With the view to the need of human medicine of a product stimulating sexual function, Tribestan was formulated on the base of the indicated phytochemical product. It contains saponins of furostanol type (Tomova M. et al., 1978). The first studies of Tribestan confirmed its high sex-stimulating activity in experimental animals (Zarkova S., 1981). Later, the clinical studies established a similar stimulating effect in humans as well (Protich M. at al. 1981). The present study was carried out with a view to throwing light on some aspects of the mechanism of that action of Tribestan, aiming at attaining an effect from the product on the serum concentration of some hypophyseal, sexual and adrenal hormones.

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2. Gauthaman, K. and Ganesan, A. – The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction – an evaluation using primates, rabbit and rat. Phytomedicine (2008) 15: 44.

Hormonal effects of Tribulus terrestris (TT) were evaluated in primates, rabbit and rat to identify its usefulness in the management of erectile dysfunction (ED). TT extract was administered intravenously, as a bolus dose of 7.5, 15 and 30 mg/kg, in primates for acute study. Rabbits and normal rats were treated with 2.5, 5 and 10mg/kg of TT extract orally for 8 weeks, for chronic study. In addition, castrated rats were treated either with testosterone cypionate (10mg/kg, subcutaneously; biweekly for 8 weeks) or TT orally (5mg/kg daily for 8 weeks). Blood samples were analyzed for testosterone (T), dihydrotestosterone (DHT) and dehydroepiandrosterone sulphate (DHEAS) levels using radioimmunoassay. In primates, the increases in T (52%), DHT (31%) and DHEAS (29%) at 7.5mg/kg were statistically significant. In rabbits, both T and DHT were increased compared to control, however, only the increases in DHT (by 30% and 32% at 5 and 10mg/kg) were statistically significant. In castrated rats, increases in T levels by 51% and 25% were observed with T and TT extract respectively that were statistically significant. TT increases some of the sex hormones, possibly due to the presence of protodioscin in the extract. TT may be useful in mild to moderate cases of ED.

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3. Justino Mameri Filho; Mauro Abi Haidar; José Maria Soares Júnior; Edmund Chada Baracat – Effects of the association of estrogen and androgen in postmenopausal women

PURPOSE: to evaluate the effects of the association of estrogen and androgen on the quality of life and sexuality of women during climacterium.
METHODS: ninety-six postmenopausal women with vasomotor symptoms and sexual dysfunction were included. The participants were randomly divided into three treatment groups with 32 pacients each: placebo, conjugated equine estrogens (CEE) (0.625 mg per day) and CEE (0.625 mg per day) associated with methyltestosterone (2.5 mg per day). The length of the treatment period was three months. The Women Health Questionnaire (WHQ) and the Modified Sexuality Questionnaire were applied to evaluate the quality of life and sexuality before and after the treatment. Some parameters of cardiovascular risk, endometrial echo and hepatic toxicity were evaluated. ANOVA was used for data analysis followed by the Fisher test and the Shapiro-Wilk post hoc test.
RESULTS: the improvement in WHQ parameters was significant in the hormonal treatment groups (CEE and CEE + methyltestosterone) compared to the placebo group. However, there were no differences in somatic symptoms among the three groups. The association of estrogen with androgen significantly improved sexual function (score (mean): 64 vs 67, p<0.05) and depressive humor (score (mean): 75 vs 80, p<0.05) compared to estrogen alone. This therapy also presented a large number of WHQ questions with a high score (p<0.05). The use of CEE associated with methyltestosterone decreased the total cholesterol (212±42 and 194±43, before and after the treatment, respectively) and HDL colesterol (56±16 and 48±14, before and after the treatment, respectively), and slightly increased the endometrial echo (4.7±2.3 and 5.5±2.3, before and after the treatment, respectively). No signifcant changes in liver enzymes during the treatment period was detected.
CONCLUSIONS: estrogen associated with methyltestosterone resulted in significant improvement in the quality of life and sexuality of postmenopausal women. This effect was superior to estrogen alone and placebo. The effect of treatment with the estrogen-androgen association was evident regarding depressive humor and sexual function questions of the WHQ.

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4. Roaiah, M., El Khayat, Y., GamalEl Din, S. and Abd El Salam, M. – Pilot Study on the Effect of Botanical Medicine (Tribulus terrestris) on Serum Testosterone Level and Erectile Function in Aging Males With Partial Androgen Deficiency (PADAM). J Sex Marital Ther. (2016) 42: 297.

This study was conducted on 30 consecutive male patients presenting to Kasr-Al Ainy Andrology outpatient clinic complaining of manifestations of partial androgen deficiency in aging males (PADAM). In this study (750 mg/day) of Tribulus terrestris in 3 divided doses, each of 250 mg, as an endogenous testosterone enhancer had been tried for a duration of 3 months and the evaluation of its effect had been monitored for each patient concerning its effect on serum testosterone (total and free) and luteinizing hormone (LH), as well as its impact on erectile function, which was evaluated by the International Index of Erectile Function-5 (IIEF-5) questionnaire for those patients. Results showed a statistically significant difference in the level of testosterone (total and free) and IIEF-5, but no statistically significant difference in the level of LH before and after treatment. Also, the study showed statistically significant correlation between testosterone (total and free) and IIEF-5, but no statistically significant correlation between the level of LH and the IIEF-5 before and after treatment.

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5. Dr. Pavleta Tabakova, Dr. Mitko Dimitrov, Dr. Bozihdar Tashkov (Head Physician), Director of Studies: (Prof. Dr. S. Dokumov) – Clinical treatment with Tribestan (Pharmachim) in women with climacteric syndrome

6. de Souza, K., Vale, F. and Geber, S. – Efficacy of Tribulus terrestris for the treatment of hypoactive sexual desire disorder in postmenopausal women: a randomized, double-blinded, placebo-controlled trial. Menopause (2016) 23: 1252.

The objective of this study was to evaluate the efficacy of Tribulus terrestris for the treatment of hypoactive sexual desire disorder in postmenopausal women and evaluate its effect on the serum levels of testosterone.
We performed a prospective randomized, double-blinded, placebo-controlled study, during 18 months. A total of 45 healthy sexually active postmenopausal women reporting diminished libido were selected to participate in the study and were randomly assigned to receive 750 mg/d of T terrestris or placebo for 120 days. Randomization was performed using sealed envelopes. All participants answered the Female Sexual Function Index and the Sexual Quotient-female version questionnaires and had their serum levels of prolactin, thyroid-stimulating hormone, total testosterone, and sex hormone-binding globulin measured. A total of 36 participants completed the study, because 3 from each group were excluded due to side effects and 3 dropped out due to personal reasons. FSFI questionnaire results demonstrated an improvement in all domains in both groups (P < 0.05) except for lubrication which was improved only in the study group. QS-F results showed a significant improvement in the domains of desire (P < 0.01), arousal/lubrication (P = 0.02), pain (P = 0.02), and anorgasmia (P < 0.01) in women who used T terrestris, whereas no improvement was observed in the placebo group (P > 0.05). Moreover, free and bioavailable testosterone levels showed a significant increase in the T terrestris group (P < 0.05). Tribulus terrestris might be a safe alternative for the treatment of hypoactive sexual desire disorder in postmenopausal women, because it was effective in reducing symptoms with few side effects. Its probable mechanism of action involves an increase in the serum levels of free and bioavailable testosterone.

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7. Karimi Jashni, Malekzadeh Shiravani, Hoshmand – The effect of the Tribulus terrestris extract on spermatogenesis in the rat

According to our antecedents, in addition to other pharmacological properties, Tribulus terrestris
increases sexual functioning and libido in men. Due to the fact that the benefits of herbal drugs should be approved clinically in the laboratory, the present study aimed to investigate the effect of Tribulus terrestris extract on the primary spermatocyte in rat.
Material and Methods:
In this experimental study, thirty five mature male Wistar rats with average weight of 180 ± 10 g and age of 2-3 months were randomly divided into five groups of seven each. Group I served as a control and group II as a experiment group (normal saline, 2.5 ml) and groups III, IV and V were treated with three different doses of oral TT extract (2.5, 5 and 10 mg/kg body weight, respectively) once daily for 8 weeks. After the last treatment, the rats were sacrificed and their testis was removed, fixed and studied using light microscope. The data were analyzed using Anova.
Results:
The results of this study showed that the mean number of primary spermatocytes in the 3rd experimental group (10 mg/kg/body) increased significantly compared with the control group (P<0.01). But Tribulus terrestris extract had no effect on the mean number of primary spermatocytes in the other experimental groups.
Conclusion:
The above results showed that Tribulus terrestris can probably balance the functions of the male reproductive system and can be used in treatment of male infertility, while effecting the testis spermatocyte.

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8. Postigo, Lima, Yamada, dos Reis, da Silva, Aoki – Assessment of the Effects of Tribulus Terrestris on Sexual Function of Menopausal Women.

OBJECTIVE:
The aim of this study was to study the effects of Tribulus terrestris on sexual function in menopausal women.
METHODS:
This was a prospective, randomized, double-blind, placebo-controlled clinical trial that included 60 postmenopausal women with sexual dysfunction. The women were divided into two groups, placebo group and Tribulus group, and evaluated by using the Sexual Quotient-female version (SQ-F) and Female Intervention Efficacy Index (FIEI) questionnaires.
RESULTS:
There was no significant difference between the groups in age, age at menopause, civil status, race, and religion. In the evaluation with the SQ-F questionnaire, there were significant differences between the placebo (7.6 ± 3.2) and Tribulus (10.2 ± 3.2) groups in the domains of desire and sexual interest (p ≤ 0.001), foreplay (3.3 ± 1.5 versus 4.2 ± 1.0) (p ≤ 0.01), arousal and harmonious interaction with the partner (5.7 ± 2.1 versus 7.2 ± 2.6) (p ≤ 0.01), and comfort in sexual intercourse (6.5 ± 2.4 versus 8.0 ± 1.9) (p ≤ 0.01). There was no significant difference between the placebo and Tribulus groups in the domains of orgasm and sexual satisfaction (p = 0.28). In the FIEI questionnaire, there was a significant improvement (p < 0.001) in the domains of vaginal lubrication during coitus and/or foreplay (20 versus 83.3%), sensation in the genitalia during sexual intercourse or other stimuli (16.7 versus 76.7%), sensation in the genital region (20 versus 70%), sexual intercourse and/or other sexual stimulations (13.3 versus 43.3%), and the ability to reach orgasm (20% versus 73.3%). There was no significant difference in adverse effects between the two groups.
CONCLUSIONS:
After 90 days of treatment, at the doses used, we found Tribulus terrestris to be effective in treating sexual problems among menopausal women.

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9. Kostova, I. & Dinchev, D. Saponins in Tribulus terrestris – Chemistry and Bioactivity. Phytochem Rev (2005) 4: 111.

Tribulus terrestris is a valuable herb known for its application in the folk medicine in many parts of the world. Furostanol and spirostanol saponins of tigogenin, neotigogenin, gitogenin, neogitogenin, hecogenin, neohecogenin, diosgenin, chlorogenin, ruscogenin and sarsasapogenin type are frequently found in this plant. Four sulphated saponins of tigogenin and diosgenin type are also isolated. Extracts and steroidal saponins have been found to possess various pharmacological activities. Preparations based on the saponin fraction of T. terrestris are used for treatment of infertility and libido disorders in men and women, as well as for treatment of cardiac diseases. Food supplements containing T. terrestris extracts are on sale in USA and Europe with claim of a general stimulating action.

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10. Salgado, Marques-Silva, Gonçalves, Mathias, Aguiar, Wolff. – Effect of oral administration of Tribulus terrestris extract on semen quality and body fat index of infertile men

Male fertility can be evaluated through complete semen analysis. Plants belonging to the Tribulus genus are known for their role in enhancing sex hormone levels and semen quality. The aim of this study was to evaluate the effects of T. terrestris on semen quality and physiological parameters. Sixty-five men with abnormal semen evaluation were included in this study, in which they were prescribed with oral administration of Androsten® (250 mg of Tribulus terrestris dried extract per capsule). Body fat percentage, lean muscle mass gain, fluctuation in steroid hormone levels and all semen parameters were analysed during the period of treatment. The results demonstrated that decrease in the percentage of body fat and increase in lean mass were significant, as well as increase in dihydrotestosterone levels. Complete semen analysis evaluated at the end of treatment showed significant enhancement in sperm concentration, motility and liquefaction time. Protodioscin, the main phytochemical agent of the Tribulus genus, acts on sertoli cells, germ cell proliferation and growth of seminiferous tubules. This component is known to convert testosterone into dihydrotestosterone, which plays important roles in male attributes. Our results indicate the therapeutic use of Tribulus terrestris by men presenting altered semen parameters, and/or undergoing infertility treatment.

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11. Jameel Mohd, Ansari Javed Akhtar, Ali Abuzer, Ahamad Javed, Ali M., Tamboli Ennus – Pharmacological scientific evidence for the promise of Tribulus terrestris

The usage of plants, plant extracts or plant-derived pure chemicals for disease management, become a therapeutic modality, which has stood the test of time. In the present r eview, we focus on pharmacological profile (in tabular form) of Tribulus terrestris L., apart from Phytochemistry, Taxonomy and Traditional uses. Data were l ocated, selected and extracted from SCI database, Medline, Pubmed, Highwire a nd Google Scholar. Fruits and seeds of Tribulus terrestris L., (Zygophyllaceae) are of immense importance in oriental medicine because they are used as an aphrodisiac, diuretic and anthelmintic, as well as to treat coughs and kidney failure. Tribulus terrestris L. has reported to have antimicrobial, antihypertension, diuretic, antiacetylcholine, haemolytic activity, spermatogenesis
and libido enhancer, antitumor activity and effects on cardiovascular system. Furostanol and spirostanol saponins, flavonoid glycosides, alkaloids, steroidal saponins named terrestrosins A, B, C, D and E, F-gitonis, gitnin and amides have been reported to occur in Tribulus terrestris L. T raditionally T. terrestris is used in folk medicine a s a tonic, aphrodisiac, palliative, a stringent, stomachic, antihypertensive, diuretic, lithon-triptic, cordial drug and uri nary anti-infective. The ash of the whole plant is good for external application in rheumatic-arthritis.

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12. Naveen Khatak & Pradeep Kumar Singh – Beneficial effect of aqueous extract of Tribulus terrestris on serum glutamate pyruvic transaminase in albino rat

In recent times focus on plant research has increased all over the world and a large number of evidences have collected to show immense potential of medicinal plant used in various traditional system. More than 1300 plants have been studied during last ten-years period (Solecki, 1975). Seven of these are medicinal plants still used throughout the herbal world (Bensky and Gamble, 1993). The ancient cultures people methodically and scientifically collect information on herbs and developed well-defined herbal pharmacopoeias. Indeed swell into 20th century much of the pharmacopoeia of scientific medicine was derived from the herbal lore of native people. Many drugs including strychnine, aspirin, taxol, curare and ergot are of herbal origin. About one quarter of the prescription drugs dispensed by community pharmacies in the United States contain at least one active ingredient derived from the plant material (Farnsworth et al., 1985 and Acherknecht, 1973).
Tribulus terrestris has many medicinal uses. It has been a constituent in tonics in Indian Ayurveda practice, where it is known by its Sanskrit name “gokshura”. (MHFW, Government of India, 2001). It is also used as an aphrodisiac in Ayurveda. Some have compared the tonic properties of Tribulus terrestris to the effects of ginseng, but these occur due to entirely different mechanisms. Serum Glutamate Pyruvic Transaminase (SGPT) is the member of the transaminase family of enzymes. Transaminase referred to as transaminase amino trasnferases; facilitate mainly in the liver, catalyses the transfer of amino groups between L-alanine and glutamate to meet physiological needs. SGPT is found in large amounts in the liver and small amounts of this enzyme are found in the heart, muscle and kidney. When the liver is injured or inflamed, the levels of in the blood usually rise; therefore, this test is performed to check for signs of liver diseases. When body tissue or an organ such as the heart or liver is damaged, additional SGPT is released into the blood stream. The amount of SGPT in the blood is directly related to the extent of the tissue damage (Nicholas and Strevens, 2003 and De Ritis et al., 1972). Therefore, the aim of this present work is to examine the effect of the oral administration of aqueous extract of Tribulus terrestris on Serum Glutamate Pyruvic Transaminase in Albino rat (Rattus norvegicus).

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13. Saurabh Chhatre, Tanuja Nesari, Gauresh Somani, Divya Kanchan, and Sadhana Sathaye – Phytopharmacological overview of Tribulus terrestris

Tribulus terrestris (family Zygophyllaceae), commonly known as Gokshur or Gokharu or puncture vine, has been used for a long time in both the Indian and Chinese systems of medicine for treatment of various kinds of diseases. Its various parts contain a variety of chemical constituents which are medicinally important, such as flavonoids, flavonol glycosides, steroidal saponins, and alkaloids. It has diuretic, aphrodisiac, antiurolithic, immunomodulatory, antidiabetic, absorption enhancing, hypolipidemic, cardiotonic, central nervous system, hepatoprotective, antiinflammatory, analgesic, antispasmodic, anticancer, antibacterial, anthelmintic, larvicidal, and anticariogenic activities. For the last few decades or so, extensive research work has been done to prove its biological activities and the pharmacology of its extracts. The aim of this review is to create a database for further investigations of the discovered phytochemical and pharmacological properties of this plant to promote research. This will help in confirmation of its traditional use along with its valueadded utility, eventually leading to higher revenues from the plant.

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 

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