VemoHerb Ecdysterone

30.50 

Description

95% pure Beta-ecdysterone extracted from the plant Leuzea carthamoides – Increases protein synthesis, muscle growth, strength and endurance. Amazing natural muscle support.*

How and Why It Works?

The properties of VemoHerb® Ecdysterone are due to the purified active ingredient, 95% beta-ecdysterone, which is isolated from the plant Leuzea carthamoides, also called Rhaponticum carthamoides or Maral root. [1] They are based on the natural muscle growth, adaptive properties of the ecdysones and lack any toxic effects during extended use.* [1-7]

The Leuzea carthamoides extract can be applied to increase the work capacity, support stress response and adaptability to everyday challenges. [1, 2, 4, 5, 12] Phytoecdysteroids stimulate protein synthesis.* [1, 2, 5, 7, 10] In doses of 5-10 mg per kg bodyweight they are referred to as protein stimulants, promoting fast muscle growth and strength.* [2, 4, 5, 7, 11, 12] As polyhydroxy sterols, they affect the metabolism of carbohydrates and nucleic acids, help glycogen synthesis and increase the content of high energy phosphate compounds (ATP).* [10, 12] This promotes the growth of skeletal muscles and positively influences the endurance, reflexes, and physical condition of athletes.* [2, 4, 5, 7, 10, 12]

A number of studies show the anabolic activity of beta-ecdysterone, as well as its harmlessness and safety for using during intense trainings or physical overwork.* [3-6, 8, 9] Also, beta-ecdysterone influences positively the function of the central nervous and sexual systems.* [1, 10, 13-15] It is used for achieving physical and psychical stability, speed, endurance, etc., and so it is recommended in a wide range of sports. [2, 7, 10, 12] VemoHerb® Ecdysterone has no side effects on the cardiovascular and immune systems, making it the perfect choice for achieving your goals.* During intense trainings, it supports the body’s ability to recover faster, increases the blood supply to the muscles and brain and maintains the proper energetic metabolism of the organism.* [1, 10, 12, 15]

VemoHerb® Ecdysterone is recommended for:

  • intense training and mental agility of athletes*
  • helping with recovery due to exhaustion from exercise*
  • supporting the stability of the body when tired from workouts*
  • muscle growth, strength and stamina*

The pack contains

90 capsules

Active substances in one capsule

245,0 mg beta-ecdysterone, extracted from the plant Leuzea carthamoides (Rhaponticum carthamoides)

Recommended daily dose

Take 1 – 2 capsules 2 times a day

Directions for use

Take between the meals or as directed on the label.

The product is a food supplement not a medical drug. The product is not a substitute for a varied diet. Do not exceed the recommended daily dose. It is not recommended for pregnant, nursing women and children!

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Ecdysterone (Leuzeae carthamoides)

Additional studies:

Experiments have been conducted, comparing the results achieved by commonly used anabolic stimulants against Leuzea carthamoides extract. They have concluded that the results of both groups were comparable, however Leuzea extract administration lacked any of the side effects of the anabolic stimulants.* [4, 5, 8-11]

The evidence is limited and not conclusive.

References:

1. Kokoska, L. and Janovska, D. – Chemistry and pharmacology of Rhaponticum carthamoides: A review. Phytochemistry (2009) 70: 842.

Rhaponticum carthamoides (Willd.) Iljin is a perennial herb, commonly known as a maral root or Russian leuzea, which has been used for centuries in eastern parts of Russia for its marked medicinal properties. This review based on 117 literary sources, with many of them being originally published in non-English languages (mainly in Russian), discusses the current knowledge of traditional uses, chemistry, biological effects and toxicity of this species. Several different classes of compounds were previously isolated from various parts of R. carthamoides of which the main groups are steroids, particularly ecdysteroids, and phenolics (flavonoids and phenolic acids) accompanied with polyacetylenes, sesquiterpene lactones, triterpenoid glycosides and terpenes (essential oil). A comprehensive account of the chemical constituents is given in this review (figures of 120 structures are shown). Various types of preparations, extracts and individual compounds derived from this species have been found to possess a broad spectrum of pharmacological effects on several organs such as the brain, blood, cardiovascular and nervous systems as well as on different biochemical processes and physiological functions including proteosynthesis, work capacity, reproduction, and sexual function. Moreover, the extracts and preparations from the plant, which are hopefully safe, exhibited various additional biological effects e.g. antioxidant, immunomodulatory, anticancerogenic, antimicrobial.

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2. Gorelick-Feldman, J., MacLean, D., Ilic, N., Poulev, A., Lila, M., Cheng, D. and Raskin, I. – Phytoecdysteroids Increase Protein Synthesis in Skeletal Muscle Cells. J Agric Food Chem. (2008) 56: 3532.

Phytoecdysteroids, which are structurally similar or identical to insect molting hormones, produce a range of effects in mammals, including increasing growth and physical performance. To study the mechanism of action of phytoecdysteroids in mammalian tissue, an in vitro cellular assay of protein synthesis was developed. In C2C12 murine myotubes and human primary myotubes, phytoecdysteroids increased protein synthesis by up to 20%. In vivo, ecdysteroids increased rat grip strength. Ecdysteroid-containing plant extracts produced similar results. The effect was inhibited by a phosphoinositide kinase-3 inhibitor, which suggests a PI3K-mediated mechanism.

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3. Wu, J., Gao, L., Shang, L., Wang, G., Wei, N., Chu, T., Chen, S., Zhang, Y., Huang, J., Wang, J. and Lin, R. – Ecdysterones from Rhaponticum carthamoides (Willd.) Iljin reduce hippocampal excitotoxic cell loss and upregulate mTOR signaling in rats. Fitoterapia (2017) 119: 158.

Glutamate-induced excitotoxicity is a key pathological mechanism in many neurological disease states. Ecdysterones derived from Rhaponticum carthamoides (Willd.) Iljin (RCI) have been shown to alleviate glutamate-induced neuronal damage; although their mechanism of action is unclear, some data suggest that they enhance signaling in the mechanistic target of rapamycin (mTOR) signaling pathway. This study sought to elucidate the mechanisms underlying ecdysterone-mediated neuroprotection. We used in silico target prediction and simulation methods to identify putative ecdysterone binding targets, and to specifically identify those that represent nodes where several neurodegenerative diseases converge. We then used histological analyses in a rat hippocampal excitotoxicity model to test the effectiveness of ecdysterones in vivo. We found that RCI-derived ecdysterones should bind to glutamatergic NMDA-type receptors (NMDARs); specifically, in vivo modeling showed binding to the GRIN2B subunit of NMDARs, which was found also to be a node of convergence in several neurodegenerative disease pathways. Computerized network construction by using pathway information from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database showed putative links between GRIN2B and mTOR pathway elements including phosphoinositide-3kinase (PI3K), mTOR, and protein kinase C (PKC); these elements are associated with neuronal survival. Brain tissue western blots of ecdysterone-treated rats showed upregulated PI3K, Akt, mTOR, and phosphorylated Akt and mTOR, and down regulated GRIN2B and the apoptotic enzyme cleaved caspase-3. Ecdysterone treatment also prevented glutamate-induced rat hippocampal cell loss. In summary, RCI-derived ecdysterones appear to prevent glutamatergic excitotoxicity by increasing mTOR/Akt/PI3K signaling activity.

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4. Toth, Noemi; Szabo, Andras; Kacsala, Peter; Heger, Julia; Zador, Erno – 20Hydroxyecdysone increases fiber size in a musclespecific fashion in rat.

20Hydroxyecdysone (20E) is an ecdysteroid hormone that regulates moulting in insects. Interestingly, 20E is also found most abundantly in plant species and has anabolic effects in vertebrates, i.e. increasing muscle size without androgen influence. The effect of 20E on slow and fast fiber types of skeletal muscle has not been reported yet. Here we present that 20E affects the size (crosssectional area, CSA) of the different fiber types in a musclespecific manner. The effect on fiber size was modified by the distance from the site of the treatment and the presence of a regenerating soleus muscle in the animal. Besides the fiber size, 20E also increased the myonuclear number in the fibers of normal and regenerating muscles, suggesting the activation of satellite cells. According to our results 20E may provide an alternative for substitution of anabolicandrogenic steroids in therapeutic treatments against muscle atrophy.

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5. Chermnykh NS, Shimanovskiĭ NL, Shutko GV, Syrov VN – The action of methandrostenolone and ecdysterone on the physical endurance of animals and on protein metabolism in the skeletal muscles

The results of the comparative study on the myotropic activity of methandrostenolone and ecdysterone and their effects on physical endurance of animals suggested that ecdysterone possessing a wider spectrum of the anabolic action on the contractile proteins of the skeletal muscles exerts a more pronounced influence on physical endurance of animals without their preliminary training.

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6. Pablo Kizelsztein, Dmitry Govorko, Slavko Komarnytsky, Alysa Evans, Zhong Wang, William T. Cefalu, and Ilya Raskin20-Hydroxyecdysone decreases weight and hyperglycemia in a diet-induced obesity mice model

The steroid hormone 20-hydroxyecdysone (20HE) is an essential signaling molecule that modulates molting response in insects and may function as a putative anabolic factor in vertebrate animals, although no mammalian 20HE receptor has been identified. Here we show that in H4IIE cell culture, 20HE treatment decreased expression of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), reduced glucose production, and induced Akt2 phosphorylation sensitive to the phosphoinositide-3 kinase pathway-specific inhibitor LY-294002. Daily oral administration of 20HE (10 mg/kg for 13 wk) ameliorated obesity and insulin resistance in C57BL/6J mice fed a high-fat diet and produced a significant decrease of body weight gain and body fat mass compared with nontreated animals as demonstrated by dual-energy X-ray absorptiometry analysis. In addition, plasma insulin levels and glucose tolerance were significantly lowered by 20HE treatment. These changes were accompanied by the reduced hepatic expression of PEPCK and G6Pase and increased adiponectin production by visceral fat tissue. These studies demonstrate the anti-obesity and anti-diabetic effects of 20HE and begin to elucidate its putative cellular targets both in vitro and in vivo.

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7. Jonathan Gorelick-Feldman, David MacLean, Nebojsa Ilic, Alexander Poulev, Mary Ann Lila, Diana Cheng and Ilya Raskin – Phytoecdysteroids Increase Protein Synthesis in Skeletal Muscle Cells

Phytoecdysteroids, which are structurally similar or identical to insect molting hormones, produce a range of effects in mammals, including increasing growth and physical performance. To study the mechanism of action of phytoecdysteroids in mammalian tissue, an in vitro cellular assay of protein synthesis was developed. In C2C12 murine myotubes and human primary myotubes, phytoecdysteroids increased protein synthesis by up to 20%. In vivo, ecdysteroids increased rat grip strength. Ecdysteroid-containing plant extracts produced similar results. The effect was inhibited by a phosphoinositide kinase-3 inhibitor, which suggests a PI3K-mediated mechanism.

Read more

8. Gadzhieva, RM, Portugalov, SN, Paniushkin, VV, Kondrat'eva II. – A comparative study of the anabolic action of ecdysten, leveton and Prime Plus, preparations of plant origin Eksp Klin Farmakol. (1995) 58: 46.

A new class of anabolic substances includes different saponins, originated from Leuzea rhaponticum sp. The effect of these substances on the human body was studied by caliperometric measurements of body folds. All tested substances taken orally for three weeks diminished fat content under conditions of daily aerobic-anaerobic training. Ekdisten and Prime Plus (combination of ekdisten and pure protein) elevated the muscle mass. The same effect of leventon was less pronounced. We showed that all substances studied elevated the magnitude of “total work”, estimated per 1 kg of body weight. Ekdisten and Prime Plus again appeared to be most efficient. The prospects of using the saponins in sport medicine are discussed.

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9. Syrov, VA, Kurmukov, AG. – On the anabolic activity of phytoecdisone-ecdisterone extracted from Rhaponticum carthamoides. Farmakol Toksikol. (1976) 39: 690.

Introduction of phytiexdizone-exdisterone (0.5 mg/100 g) to rats for 7 days is shown to be attended by an accelerated body weight gain and also by a rising weight of the liver, heart, kidneys and musculus tibialis anterior. In these organs the total amount of protein increases. All of the above-stated changes are more marked when the substance is given to growing rats (70–80 g). In experiments on castrated sexually immature rats the androgenic action of exdisterone, unlike that of methandrostenolone, is not demonstrable.

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10. Donald Yance, CN, AHG, SFO – Rhaponticum carthamoides

Rhaponticum carthamoides (Willd.) Iljin, syn. Leuzea carthamoides (Willd.) DC, is a large perennial herb in the Compositae family. R. carthamoides has a wood-like horizontal rhizome, multiple long, hard roots, and is capable of growing to a height of over 6 feet. R. carthamoides grows in the pristine alpine and subalpine zones and alpine meadows of Southern Siberia. The roots and rhizomes are the medicinal parts, with the biological activity determined by phytoecdystone quantity, including ecdysterone.

This herb is a hidden jewel. R. carthamoides extract (RCE) has demonstrated a normalizing effect on the central nervous and cardiovascular systems. RCE improves sleep, appetite, moods, mental and physical state, and the functional ability of humans under working conditions. It is a classic adaptogen possessing a wide spectrum of anabolic activities, acting on the contractile proteins of the skeletal muscles, as well as on other areas of the body including the liver, heart, kidneys, and brain. It builds lean muscle, reduces body fat, improves work and/or athletic performance, improves mental acuity, relieves depression, is a tonic for the vital organ systems, is a reliable blood- building tonic, and delays the effects of aging. It is useful for both andropause and menopause.

11. R. Lafont and L. Dinan – Practical uses for ecdysteroids in mammals including humans: and update

Ecdysteroids are widely used as inducers for gene-switch systems based on insect ecdysteroid receptors and genes of interest placed under the control of ecdysteroid-response elements. We review here these systems, which are currently mainly used in vitro with cultured cells in order to analyse the role of a wide array of genes, but which are expected to represent the basis for future gene therapy strategies. Such developments raise several questions, which are addressed in detail.

First, the metabolic fate of ecdysteroids in mammals, including humans, is only poorly known, and the rapid catabolism of ecdysteroids may impede their use as in vivo inducers.

A second set of questions arose in fact much earlier with the pioneering “heterophylic” studies of Burdette in the early sixties on the pharmacological effects of ecdysteroids on mammals. These and subsequent studies showed a wide range of effects, most of them being beneficial for the organism (e.g. hypoglycaemic, hypocholesterolaemic, anabolic). These effects are reviewed and critically analysed, and some hypotheses are proposed to explain the putative mechanisms involved.

All of these pharmacological effects have led to the development of a wide array of ecdysteroid-containing preparations, which are primarily used for their anabolic and/or “adaptogenic” properties on humans (or horses or dogs). In the same way, increasing numbers of patents have been deposited concerning various beneficial effects of ecdysteroids in many medical or cosmetic domains, which make ecdysteroids very attractive candidates for several practical uses.

It may be questioned whether all these pharmacological actions are compatible with the development of ecdysteroid-inducible gene switches for gene therapy, and also if ecdysteroids should be classified among doping substances.

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12. David Winston, Steven Maimes – Adaptogens: Herbs for Strength, Stamina, and Stress Relief

The definitive guide to adaptogenic herbs, formerly known as “tonics,” that counter the effects of age and stress on the body.

Reveals how adaptogens increase the body’s resistance to adverse influences

Provides a history of the use of these herbal remedies and the actions, properties, preparation, and dosage for each herb

We all deal with stress every day, and every day our bodies strive to adapt and stay balanced and healthy. In Adaptogens, authors David Winston and Steven Maimes provide a comprehensive look into adaptogens, non-toxic herbs such as ginseng, eleuthero, and licorice, that produce a defensive response to stress in our bodies. Formerly known as rejuvenating herbs or tonics, adaptogens help the body to “adapt” to the many influences it encounters. They increase stamina and counter the normal effects of aging and thus are becoming important tools in sports medicine and in the prevention and treatment of chronic fatigue and other stress-related disorders.

Winston and Maimes present the historical uses of these herbal remedies in India, Russia, China, and the Americas and explain how they work and why they are so effective at combating stress-induced illness. Monographs for each adaptogen also present the latest scientific research and include the origin, traditional use, actions, properties, preparation, and dosage for each herb.

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13. Aviva Romm – Elsevier Health Sciences

Use herbal medicines to treat women at any stage of life! Botanical Medicine for Women’s Health, 2nd Edition provides an evidence-based, patient-centered approach to botanical interventions for many different medical conditions. More than 150 natural products are covered, showing their benefits in gynecologic health, fertility and childbearing, and menopausal health. This edition includes new full-color photos of herbal plants along with a discussion of the role of botanicals in healthy aging. Written by Aviva Romm, an experienced herbalist, midwife, and physician, this unique guide is an essential resource for everyday practice of herbal medicine.

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14. Mirzaev IuR, Syrov VN, Khrushev SA, Iskanderova SD – Effect of ecdystene on parameters of the sexual function under experimental and clinical conditions

The effects of ecdysterone and the related drug ecdysten on the sexual activity were studied under experimental and clinical conditions. A 10-day administration of ecdysterone (5 and 10 mg/kg, p.o.) improved behavioral characteristics of the sexual function in rats, the effect being especially pronounced during the fist days of experiment. The administration of ecdysten to men with the infertility diagnosis (disturbed spermatogenesis as a complication of some urologic diseases) increased the copulative function and improved the sperm quality. The administration of ecdysten to patients in the stage of recovery upon myocardial infarction also improved the sexual function.

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15. Ladislav Kokoska a, Dagmar Janovska – Chemistry and pharmacology of Rhaponticum carthamoides

Rhaponticum carthamoides (Willd.) Iljin is a perennial herb, commonly known as a maral root or Russian leuzea, which has been used for centuries in eastern parts of Russia for its marked medicinal properties. This review based on 117 literary sources, with many of them being originally published in non-English languages (mainly in Russian), discusses the current knowledge of traditional uses, chemistry, biological effects and toxicity of this species. Several different classes of compounds were previously isolated from various parts of R. carthamoides of which the main groups are steroids, particularly ecdysteroids, and phenolics (flavonoids and phenolic acids) accompanied with polyacetylenes, sesquiterpene lactones, triterpenoid glycosides and terpenes (essential oil). A comprehensive account of the chemical constituents is given in this review (figures of 120 structures are shown). Various types of preparations, extracts and individual compounds derived from this species have been found to possess a broad spectrum of pharmacological effects on several organs such as the brain, blood, cardiovascular and nervous systems as well as on different biochemical processes and physiological functions including proteosynthesis, work capacity, reproduction, and sexual function. Moreover, the extracts and preparations from the plant, which are hopefully safe, exhibited various additional biological effects e.g. antioxidant, immunomodulatory, anticancerogenic, antimicrobial, antiparasitic and insect antifeedant or repellent activities. The results of data analysis on the chemical, pharmacological and toxicological characteristics of R. carthamoides support the view that this species has beneficial therapeutic properties and indicate its potential as an effective adaptogenic herbal remedy. Finally, some suggestions for further research on chemical and pharmacological properties are given in this review.

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 

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