VemoHerb Cichorium

7.50 

Description

Dietary supplement based on premium quality dry extract from the aerial part of the plant Cichorium intybus, with a content of min. 8% flavonoids, determined as apigenin; 10% coumarins, determined as esculin; and min. 5% tannic compounds, determined as tannin.

Supports liver, kidneys and gall health, naturally*

How and Why It Works?

Cichorium intybus has been well known in the folk medicine as coffee substitute and is believed to overcome in a natural way mild digestive disorders, loss of appetite and its administration supports the overall health status.* [4, 6, 7] The properties of VemoHerb® Cichorium are due to the content of specific active ingredients extracted from the plant Cichorium intybus, including dihydroxycoumarin glycosides – cichoriin, esculin and esculetin.*

The content of flavonoids (apigenin, quercetin and luteolin) in the extract from Cichorium intybus helps the body rid itself of toxins, supports a positive oxygen balance in the blood and positively influences the metabolism.* [8-11]

All of the above in combination with the coumarin derivatives form the biologically-active complex of VemoHerb® Cichorium that influences positively the gall-kidney and liver functions.* Also, VemoHerb® Cichorium influences positively the glutathione levels and supports the cardio-vascular system.* [10]

VemoHerb® Cichorium supports:

the normal function of liver* [1-3]

the body’s natural processes for healthy kidneys* [4, 5]

the cardio-vascular system* [10]

normal function of gallbladder* [2]

The pack contains

60 capsules

Active substances in one capsule

200,0 mg dry extract from the aerial part of the plant Cichorium intybus, with a content of min. 8% flavonoids, determined as apigenin; 10% coumarins, determined as esculin; and min. 5% tannic compounds, determined as tannin

Recommended daily dose

1 – 3 capsules a day

Directions for use

Take between the meals or as directed on the label.

The product is a food supplement not a medical drug. The product is not a substitute for a varied diet. Do not exceed the recommended daily dose. It is not recommended for pregnant, nursing women and children!

Additional studies:

Some studies suggest that the properties of Cichorium intybus are due to the content of specific active ingredients extracted from the plant, including dihydroxycoumarin glycosides – cichoriin, esculin and esculetin, in the necessary levels that may help reduce inflammations.* [5, 7]

Further examination is required.

References:

1. Zafar R, Mujahid Ali S – Anti-hepatotoxic effects of root and root callus extracts of Cichorium intybus L.

The natural root and root callus extracts of Cichorium intybus were compared for their anti-hepatotoxic effects in Wistar strain of Albino rats against carbon tetrachloride induced hepatic damage. The increased levels of serum enymes (aspartate transaminase, alanine transaminase) and bilirubin observed in rats treated with carbon tetrachloride were very much reduced in the animals treated with natural root and root callus extracts and carbon tetrachloride. The decreased levels of albumin and proteins observed in rats after treatment with carbon tetrachloride were found to increase in rats treated with natural root and root callus extracts and carbon tetrachloride. These biochemical observations were supplemented by histopathological examination of liver sections. Results of this study revealed that Cichorium intybus root callus extract could afford a better protection against carbon tetrachloride induced heptocellular damage as compared to the natural root extract.

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2. A.H.Gilani K.H.Janbaz – Evaluation of the liver protective potential of Cichorium intybus seed extract on Acetaminophen and CCl-induced damage

The hepatoprotective activity of aqueous-methanolic extract of Cichorium intybus seeds was investigated against acetaminophen and CCl4-induced hepatic damage. Acetaminophen produced 100% mortality at the dose of 1 g/kg in mice while pretreatment of animals with plant extract (500mg/kg) reduced the death rate to 30%. Acetaminophen at the dose of 640 mg/kg produced liver damage in rats as manifested by the significant (P < 0.01) rise in serum levels of alkaline phosphatase (ALP), GOT and GPT to 393 ± 28, 767 ± 215 and 692 ± 191 IU/L (n = 10) respectively, compared to respective control values of 198 ± 15, 76 ± 07 and 39 ± 09. Pretreatment of rats with plant extract (500 mg/kg) significantly lowered (P < 0.01), the respective serum ALP, GOT and GPT levels to 228 ± 16, 68 ± 10 and 41 ± 08. Similarly, a hepatotoxic dose of CCl4 (1.5 mL/kg; orally) significantly raised (P < 0.01), the serum ALP, GOT and GPT levels to 312 ± 20, 503 ± 98 and 407 ± 109 IU/L (n = 10) respectively, compared to respective control values of 215 ± 16, 79 ± 18 and 49 ± 10. The same dose of plant extract (500 mg/kg) was able to prevent significantly (P < 0.05) the CCl4-induced rise in serum enzymes and the estimated values of ALP, GOT and GPT were 222 ± 27, 114 ± 23 and 68 ± 14 respectively. Moreover, it prevented CCl4-induced prolongation in pentobarbital sleeping time confirming hepatoprotectivity and validates the folkloric uses of this plant in liver damage.

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3. T.S. Mohamed Saleem, C. Madhusudhana Chetty, S. Ramkanth, V.S.T. Rajan, K. Mahesh Kumar, Gauthaman K – Hepatoprotective Herbs – A Review

Liver is a vital organ play a major role in metabolism and excretion of xenobiotics from the body. Liver injury or liver dysfunction is a major health problem that challenges not only health care professionals but also the phar-maceutical industry and drug regulatory agencies. Liver cell injury caused by various toxic chemicals (certain anti-biotic, chemotherapeutic agents, carbon tetrachloride (CCL4), thioacetamide (TAA) etc.), excessive alcohol con-sumption and microbes is well-studied. The available synthetic drugs to treat liver disorders in this condition also cause further damage to the liver. Hence, Herbal drugs have become increasingly popular and their use is wide-spread. Herbal medicines have been used in the treatment of liver diseases for a long time. A number of herbal preparations are available in the market. The present review is aimed at compiling data on promising phytochemi-cals from medicinal plants that have been tested in hepatotoxicity models using modern scientific system.

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4. S. Nandagopal and B.D. Ranjitha Kumari – Phytochemical and Antibacterial Studies of Chicory (Cichorium intybus L.) - A Multipurpose Medicinal Plant

Chicory (Cichorium intybus L.) belongs to the family Asteraceae and it is a small aromatic biennial or perennial herb. The whole plant contains a number of medicinally important compounds such as inulin, esculin, volatile compounds (monoterpenes and sesquiterpenes), coumarins, flavonoids and vitamins. In the present study, we evaluated the phytochemical analysis for the presence of various secondary metabolites and antibacterial activity of the root extracts of chicory against pathogenic bacteria like gram positive (Bacillus subtilis, Staphylococcus aureus and Micrococcus luteus) and gram negative (Escherichia coli and Salmonella typhi) bacteria by in vitro agar well diffusion method. The hexane and ethyl acetate root extracts of chicory showed pronounced inhibition than chloroform, petroleum ether and water extracts. Root extracts showed more inhibitory action on Bacillus subtilis, Staphylococcus aureus and Salmonella typhi than Micrococcus luteus and Escherichia coli.

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5. K. N. Venugopala,V. Rashmi,2 and B. Odhav – Review on Natural Coumarin Lead Compounds forTheir Pharmacological Activity

Coumarin (2H-1-benzopyran-2-one) is a plant-derived natural product known for its pharmacological properties such as anti-inflammatory, anticoagulant, antibacterial, antifungal, antiviral, anticancer, antihypertensive, antitubercular, anticonvulsant, antiadipogenic, antihyperglycemic, antioxidant, and neuroprotective properties. Dietary exposure to benzopyrones is significant as these compounds are found in vegetables, fruits, seeds, nuts, coffee, tea, and wine. In view of the established low toxicity, relative cheapness, presence in the diet, and occurrence in various herbal remedies of coumarins, it appears prudent to evaluate their properties and applications further.

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6. Renée A. Street, Jasmeen Sidana, and Gerhard Prinsloo – Cichorium intybus: Traditional Uses, Phytochemistry, Pharmacology, and Toxicology

The genus Cichorium (Asteraceae) is made up of six species with major geographical presence in Europe and Asia. Cichorium intybus, commonly known as chicory, is well known as a coffee substitute but is also widely used medicinally to treat various ailments ranging from wounds to diabetes. Although this plant has a rich history of use in folklore, many of its constituents have not been explored for their pharmacological potential. Toxicological data on C. intybus is currently limited. This review focuses on the economic and culturally important medicinal uses of C. intybus. Traditional uses, scientific validation, and phytochemical composition are discussed in detail.

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7. Kyung-Tae Lee, J I Kim, H J Park, K-I Miyamoto – Differentiation-Inducing Effect of Magnolialide, a 1.BETA.-Hydroxyeudesmanolide Isolated from Cichorium intybus, on Human Leukemia Cells.

Cichorium intybus contains two 1beta-hydroxyeudesmanolides, magnolialide and artesin, together with several constituents. Magnolialide inhibits the growth of several tumor cell lines and appears to induce differentiation of human leukemia HL-60 and U-937 cells to monocyte/macrophage-like cells. Another 1beta-hydroxyeudesmanolide, artesin, and other constituents were inactive. The content of magnolialide was shown to be highest in the leaves of Inje cultivar among the cultivars investigated in this study.
(PDF) Differentiation-Inducing Effect of Magnolialide, a 1.BETA.-Hydroxyeudesmanolide Isolated from Cichorium intybus, on Human Leukemia Cells.

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8. Hazra B, Sarkar R, Bhattacharyya S, Roy P. – Tumour inhibitory activity of chicory root extract against Ehrlich ascites carcinoma in mice.

The tumour-inhibitory effect of an ethanolic extract of chicory root was studied against Ehrlich ascites carcinoma in mice; significant results were obtained at doses from 300 to 700 mg/kg.

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9. Sultana S, Perwaiz S, Iqbal M, Athar M. – Crude extracts of hepatoprotective plants, Solanum nigrum and Cichorium intybus inhibit free radical-mediated DNA damage.

The presence of plant extracts of Solanum nigrum and Cichorium intybus in the reaction mixture containing calf thymus DNA and free radical generating system protect DNA against oxidative damage to its deoxyribose sugar moiety. The effect was dependent on the concentration of plant extracts. However, the effect of Cichorium intybus was much pronounced as compared to the effect of Solanum nigrum. These studies suggest that the observed hepatoprotective effect of these crude plant extracts may be due to their ability to suppress the oxidative degradation of DNA in the tissue debris.

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10. Assessment report on Cichorium intybus L.

Cichorium intybus  L, is an erect perennial herb 80±90cm in height usually with bright blue flowers, rarely white or pink. It has a fleshy taproot up to 75cm in length. Cichorium intybus is a member of the Asteraceae family. The genus Cichorium consists of six species with major distribution areas in Europ e and Asia. Member of the species are cultivated in Europe for salad leaves, chicons (blanched buds), or for roots (var. sativum), which are baked, ground, and used as a coffee substitute and additive.The name of the plant is derived from Greek and Latin.Cichorium originates from χ_ω (kio)(I go) = χωρ_ον and chorion = field i, ie, in connection with the occurrence of the plant stands. “Intybus” is partly derived from the Greek _ντομος (éntomos) = cut, because of the leaves, and partly from the Latin in = in and = tubus tube, to indicate the hollow stem. Popular common names of the plant are (Common) chicory, bluesailor’s succory and coffee weed.

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11. Adele Papetti, Maria Daglia, and Gabriella Gazzani – Anti- and Pro-oxidant Water Soluble Activity of Cichorium Genus Vegetables and Effect of Thermal Treatment

Both the pro- and antiradical water soluble activity, toward DPPH(*), ROO(*), OH(*) radicals found in seven diet vegetables belonging to the Cichorium genus, and the effects of boiling, freezing, and freeze-drying on such activities were investigated. The vegetables were three red cultivars of Cichorium intybus var. silvestre from three different areas of production, that is, chicory from Chioggia, Treviso, and Verona, C. intybus var. foliosum (Belgian chicory), C. endivia var. latifolium (escarole), C. endiviavar. crispum (“crispa”), and a hybrid vegetable obtained by the cross between C. intybus var. silvestre and C. endivia var. latifolium (chicory from Castelfranco). The juices obtained by simple centrifugation of vegetables operating at 2 or 25 degrees C and submitted to the thermal technological treatments were assessed for antiradical activity using the DPPH(*) assay, the linoleic acid-beta-carotene system, and the deoxyribose assay. In all three assays used, each vegetable juice was shown to possess antiradical activity; there was a significant level in the C. endivia and the Belgian chicories and higher levels in the red C. intybus vegetables and the hybrid vegetable. All juice behaviors in the linoleic acid-beta-carotene system indicate that they also contain a thermally unstable component, which in a cold medium promptly promoted and accelerated linoleic acid peroxidation, therefore masking the presence of any thermally stable antiperoxyl radical components. The presence of these components, which efficiently protect linoleic acid from peroxidation, can be singled out only after inactivation by heating, or separation by dialysis, of the pro-oxidant components. Dialysis fractions showed that the pro-oxidant component has MW > 50000 Da and that the juices contain a number of antioxidant components which contribute to their antiradical activity.

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 

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