VemoHerb Bulgarian Tribulus Drink

30.50 

Description

Completely natural instant drink with Bulgarian Tribulus terrestris extract, with blueberry flavour.

VemoHerb® Bulgarian Tribulus drink has an energizing effect and assists you to cope with the physical  overwork.*

How and Why It Works?*

The instant drink VemoHerb® Bulgarian Tribulus contains extract from the Bulgarian herb Tribulus terrestris. This plant is well known in the Bulgarian traditional medicine. Regarded as a vitality herb, it has been used for centuries because of its positive effect on the human energy and libido.* [1, 3, 4, 6, 7, 12]

The Bulgarian Tribulus terrestris extract manufactured by VEMO 99 Ltd is rich in active ingredients and standardized at 60% furostanol saponins determined as Protodioscin. [1, 13] The specific bouquet of furostanol saponins in the Bulgarian Tribulus terrestris have a distinct positive effect on strength, muscle growth, lean body mass, sexuality.* [1, 2, 4, 6, 7, 12]

The main difference between VEMO’s Tribulus extract and all others is not just the higher concentration of Protodioscin, but also the higher amounts of accompanying substances that modulate and amplify the effects of Protodioscin. [1, 5]

The whole group of furostanol saponins present in the extract play an important role in supporting the properties of Protodioscin. [1, 5] They maintain the optimal cholesterol levels.* The positive influence on the regulation of cholesterol levels indirectly supports the effects of the active substances from the extract on the cholesterol metabolism.* [3] It is believed that Protodioscin positively affects the production of DHEA (Dehydroepiandrosterone) which is involved in the normal steroidal synthesis, by assisting the transformation of free cholesterol into sex hormones. [1, 8] According to some scientists, the plant extract supports the luteinizing hormone synthesis and positively influences the amounts of testosterone in a natural way.* [8] Testosterone promotes muscle growth indirectly by stimulating protein synthesis in the organism.* [1, 2]

The phytochemistry of the Bulgarian Tribulus terrestris is unique due to the specific geographic position, the suitable climate and topography of the country and the specific collecting method for the herb. These factors determine the differences in the pharmacological and physiological properties and advantages of the Bulgarian herb when compared to Tribulus terrestris with foreign origin. [1, 13]

Most products, available on the market at the moment, contain extracts from India and China, with lower concentration of active ingredients and practically no physiological effect. [13]

The Bulgarian Tribulus terrestris extract assists the positive nitrogen balance and improves protein synthesis, including in the muscles.* This helps with the body capabilities and endurance in cases of physical and mental overwork.* [1, 2]

The extract VemoHerb® Bulgarian Tribulus of VEMO 99 Ltd is different from the rest extracts mainly by:

  • Using top-quality wild-grown herb, gathered at a specific phase of growth in ecologically clean regions. The herb is dried and stored according to all technological requirements to guarantee preservation and maximum content of its active substances.
  • Unique know-how technology for obtaining potent herbal extract from the plant raw material that provides 60% furostanol saponins with prevailing component Protodioscin.
  • Offering a refined herbal product with guaranteed constant quality, containing suitable combination of furostanol saponins for our clients.

The pack contains

30 sachets

Active substances in one sachet

500 mg Tribulus (aerial parts and fruit) Extract (Tribulus terrestris L.) (60% furostanol saponins determined as protodioscin)

Recommended daily dose

1 – 2 sachets a day

Directions for use

The sachet content is dissolved in 250 ml water, while stirring.

The product is a food supplement not a medical drug. The product is not a substitute for a varied diet. Do not exceed the recommended daily dose. It is not recommended for pregnant, nursing women and children!

References

1. Wenyi Zhu, Yijie Du, Hong Meng, Yinmao Dong and Li Li – A review of traditional pharmacological uses, phytochemistry, and pharmacological activities of Tribulus terrestris

Tribulus terrestris L. (TT) is an annual plant of the family Zygophyllaceae that has been used for generations to energize, vitalize, and improve sexual function and physical performance in men. The fruits and roots of TT have been used as a folk medicine for thousands of years in China, India, Sudan, and Pakistan. Numerous bioactive phytochemicals, such as saponins and flavonoids, have been isolated and identified from TT that are responsible alone or in combination for various pharmacological activities. This review provides a comprehensive overview of the traditional applications, phytochemistry, pharmacology and overuse of TT and provides evidence for better medicinal usage of TT.

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2. Rogerson, Riches, Jennings, Weatherby, Meir, Marshall-Gradisnik – The effect of five weeks of Tribulus terrestris supplementation on muscle strength and body composition during preseason training in elite rugby league players.

Tribulus terrestris is an herbal nutritional supplement that is promoted to produce large gains in strength and lean muscle mass in 5-28 days (15, 18). Although some manufacturers claim T. terrestris will not lead to a positive drug test, others have suggested that T. terrestris may increase the urinary testosterone/epitestosterone (T/E) ratio, which may place athletes at risk of a positive drug test. The purpose of the study was to determine the effect of T. terrestris on strength, fat free mass, and the urinary T/E ratio during 5 weeks of preseason training in elite rugby league players. Twenty-two Australian elite male rugby league players (mean +/- SD; age = 19.8 +/- 2.9 years; weight = 88.0 +/- 9.5 kg) were match-paired and randomly assigned in a double-blind manner to either a T. terrestris (n = 11) or placebo (n = 11) group. All subjects performed structured heavy resistance training as part of the club’s preseason preparations. A T. terrestris extract (450 mg.d(-1)) or placebo capsules were consumed once daily for 5 weeks. Muscular strength, body composition, and the urinary T/E ratio were monitored prior to and after supplementation. After 5 weeks of training, strength and fat free mass increased significantly without any between-group differences. No between-group differences were noted in the urinary T/E ratio. It was concluded that T. terrestris did not produce the large gains in strength or lean muscle mass that many manufacturers claim can be experienced within 5-28 days. Furthermore, T. terrestris did not alter the urinary T/E ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agency’s urinary T/E ratio limit of 4:1.

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3. K. Milasius, R. Dadeliene, Ju. Skernevicius – The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes’ organism homeostase

The influence of the Tribulus terrestris extract on the parameters of the functional preparadness and athletes. organism homeostase was investigated. It was established the positive impact of dietary supplement .Tribulus. (Optimum Nutrition, USA) using per 1 capsule 3 times a day during 20 days on athletes. physical power in various energy producing zones: anaerobic alactic muscular power and anaerobic alactic glycolytic power statistically reliable increased. Tribulus terrestris extract, after 20 days of consuming it, did not have essential effect on erythrocytes, haemoglobin and thrombocytes indices. During the experimental period statistically importantly increased percentage of granulocytes and decreased percentage of leucocytes show negative impact of this food supplement on changes of leucocytes formula in athletes. blood. Creatinkinase concentration in athletes. Blood statistically importantly has increased and creatinine amount has had a tendency to decline during 20 days period of consuming Tribulus terrestris extract. The declining tendency of urea, cholesterol and bilirubin concentrations has appeared. The concentration of blood testosterone increased statistically reliable during the first half (10 days) of the experiment; it did not grow during the next 10 days while consuming Tribulus still.

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4. Jameel Mohd, Ansari Javed Akhtar, Ali Abuzer, Ahamad Javed, Ali M., Tamboli Ennus – Pharmacological scientific evidence for the promise of Tribulus terrestris

The usage of plants, plant extracts or plant-derived pure chemicals for disease management, become a therapeutic modality, which has stood the test of time.

In the present r eview, we focus on pharmacological profile (in tabular form) of Tribulus terrestris L., apart from Phytochemistry, Taxonomy and Traditional uses. Data were l ocated, selected and extracted from SCI database, Medline, Pubmed, Highwire a nd Google Scholar. Fruits and seeds of Tribulus terrestris L., (Zygophyllaceae) are of immense importance in oriental medicine because they are used as an aphrodisiac, diuretic and anthelmintic, as well as to treat coughs and kidney failure. Tribulus terrestris L. has reported to have antimicrobial, antihypertension, diuretic, antiacetylcholine, haemolytic activity, spermatogenesis and libido enhancer, antitumor activity and effects on cardiovascular system. Furostanol and spirostanol saponins, flavonoid glycosides, alkaloids, steroidal saponins named terrestrosins A, B, C, D and E, F-gitonis, gitnin and amides have been reported to occur in Tribulus terrestris L. T raditionally T. terrestris is used in folk medicine a s a tonic, aphrodisiac, palliative, a stringent, stomachic, antihypertensive, diuretic, lithon-triptic, cordial drug and uri nary anti-infective. The ash of the whole plant is good for external application in rheumatic-arthritis.

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5. Mrinalini Kumari, Praveen Kumar and Poonam Singh – Safety Evaluation of Tribulus Terrestris on the Male Reproductive Health of Laboratory Mouse

Tribulus terrestris (TT) has emerged as an instant plant for the treatment of sexual dysfunctions and fertility related disorders in the males. The present study was aimed to assess the safety efficacy of the fruit extract of TT on the male reproduction. Animals of Group I served as control while that of II and III were administered with 100mg/kgBW/day and 200mg/kgBW/day of the fruit extract of TT, respectively, for 28 days. Testicular histology, sperm parameters, serum clinical biochemistry (SGOT, SGPT and creatinine) and tissue biochemistry (fructose in the seminal vesicle, sialic acid in the epididymis, antioxidant enzymes activity, LPO, LDH and ALP in the testis) were carried out to establish the safety of the fruit extract. Safety of the extract was evidenced by the unaltered body weight and serum clinical biochemistry. Administration of the fruit extract of TT neither interfered with the weights of the reproductive organs nor altered the sperm indices in the cauda epididymidis as well as the spermatogenic activity in the testis. The unaltered androgen – dependent biochemical markers i.e. sialic acid in the epididymis and fructose in the seminal vesicle indicated the normal status of the testosterone level. Unaltered activities of testicular antioxidant enzymes and the level of LPO suggest that the fruit extract does not cause oxidative stress. Further the unaltered activities of LDH and ALP in the testis represent normal physiological activity of the organ that could be correlated with the uninterrupted spermatogenic activity. It can, therefore, be concluded that the fruit extract of this herb could effectively be used as a natural remedy in treatment of male reproductive disorders without causing any side effects.

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6. A. Adimoelja – Phytochemicals: modern views and breakthrough in traditional herbal management of sexual dysfunctions

Traditional herbs have been a revolutionary breakthrough in the management of erectile dysfunction and have become known world-wide as an ‘instant’ treatment. The modern view of the management of erectile dysfunction subscribes to a single etiology, i.e. the mechanism of erection. A large number of pharmacological agents are orally consumed and vasoactive agents inserted intraurethrally or injected intrapenially to regain good erection. Modern phytochemicals have been developed from traditional herbs. Phytochemicals focus their mechanism of healing action of the root cause, i.e. the inability to control the proper function of the whole body system. Hence phytochemicals manage erectile dysfunction in the frame of sexual dysfunction as a whole entity. Protodioscin is a phytochemical agent derived from Tribulus terrestris L plant, which has been clinically proven to improve sexual desire and enhance erection via the conversion of protodioscin to DHEA (Dehydroepiandrosterone). Preliminary observations suggest that Tribulus terrestris L grown on different soils does not consistently produce the active component protodioscin. Further photochemical studies of many other herbal plants are needed to explain the inconsistent result found with other herbal plants, such as in diversities of Ginseng, Eurycoma longifolia, Pimpinella pruacen, Muara puama, Ginkgo biloba, Yohimbe etc.

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7. A.W. Nasution – Effect of Tribulus terrestris treatment on impotence and libido disorders

To test the effectiveness of Tribulus terrestris in treating impotence and male libido disorders, we enrolled 11 subjects, composed of 4 men diagnosed with lowered or nonexistent libido and 7 impotent men. To these two groups, 3 x 1 Libilov tablets were administered per day for 2 weeks, without any additional vitamin supplements or pharmaceutical therapeutics. 50% of the subjects with reduced libido reported increased sex drive after Libilov treatment. Close to 60% of impotent subjects experienced improved erection, including prolonged duration of erection after treatment. This trial suggested that even a short period of treatment with Libilov was effective in treating these two conditions. Furthermore, as with previous trials, no adverse side-effects were observed.

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8. Milanov, S., E. Maleeva, M. Tashkov. – Tribestan effect on the concentration of some hormones in the serum of healthy subjects (1981) (Company documentation).

Tribestan effect has been studied on the serum concentration of hypophyseal hormones, of ACTH, STH, LH, FSH, adrenal hormone aldosterone and cortisol and sex hormones – testosterone and estradiol. The experiments have been carried out on 8 males and 8 females, aged 28 – 45 years of age. The product was perorally administered in a single dose of 250 mg, three times daily for 5 days. Serum samples were withdrawn at 8 a.m. and 12 a.m., prior to and post treatment. The product has been established not to change essentially the concentrations of adrenal hormones and of ACTH. The hypophyseal-gonadal axis however has significantly been affected in the females with predominantly increased concentration of FSH and estradiol and in the males – mainly of LH and the testosterone. The mechanism of that action is presumed to be complicated and realized both by direct effect on gonadal apparatus and by the tropic hormones. The probable established changes in the concentration of the hormones studied do not get out of the frames of the physiological limits. The lyophilized extract of Tribulus terrestris, introduced in veterinary practice as TB-68, has pronounced sex-stimulating function. The initial studies of this product showed that it stimulates the spermatogenesis of albino rats (Vankov S., et al., 1973) and enhanced the ovulation of female rats (Vankov S. et al. 1973). Zarkova S. (1976) has also established in rats an increased number of spermatogonia, spermatocytes as well as increase of neutral mucopolysaccharides in seminiferous tubules of the testes. Gendzhev Z. and S. Zarkova, in other experiments (1978) proved the increase of spermatic reserve in the epididymis of rats. With the view to the need of human medicine of a product stimulating sexual function, Tribestan was formulated on the base of the indicated phytochemical product. It contains saponins of furostanol type (Tomova M. et al., 1978). The first studies of Tribestan confirmed its high sex-stimulating activity in experimental animals (Zarkova S., 1981). Later, the clinical studies established a similar stimulating effect in humans as well (Protich M. at al. 1981). The present study was carried out with a view to throwing light on some aspects of the mechanism of that action of Tribestan, aiming at attaining an effect from the product on the serum concentration of some hypophyseal, sexual and adrenal hormones.

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9. Justino Mameri FilhoI; Mauro Abi HaidarII; José Maria Soares JúniorIII; Edmund Chada BaracatIV – Effects of the association of estrogen and androgen in postmenopausal women

PURPOSE: to evaluate the effects of the association of estrogen and androgen on the quality of life and sexuality of women during climacterium.
METHODS: ninety-six postmenopausal women with vasomotor symptoms and sexual dysfunction were included. The participants were randomly divided into three treatment groups with 32 pacients each: placebo, conjugated equine estrogens (CEE) (0.625 mg per day) and CEE (0.625 mg per day) associated with methyltestosterone (2.5 mg per day). The length of the treatment period was three months. The Women Health Questionnaire (WHQ) and the Modified Sexuality Questionnaire were applied to evaluate the quality of life and sexuality before and after the treatment. Some parameters of cardiovascular risk, endometrial echo and hepatic toxicity were evaluated. ANOVA was used for data analysis followed by the Fisher test and the Shapiro-Wilk post hoc test.

RESULTS: the improvement in WHQ parameters was significant in the hormonal treatment groups (CEE and CEE + methyltestosterone) compared to the placebo group. However, there were no differences in somatic symptoms among the three groups. The association of estrogen with androgen significantly improved sexual function (score (mean): 64 vs 67, p<0.05) and depressive humor (score (mean): 75 vs 80, p<0.05) compared to estrogen alone. This therapy also presented a large number of WHQ questions with a high score (p<0.05). The use of CEE associated with methyltestosterone decreased the total cholesterol (212±42 and 194±43, before and after the treatment, respectively) and HDL colesterol (56±16 and 48±14, before and after the treatment, respectively), and slightly increased the endometrial echo (4.7±2.3 and 5.5±2.3, before and after the treatment, respectively). No signifcant changes in liver enzymes during the treatment period was detected.
CONCLUSIONS: estrogen associated with methyltestosterone resulted in significant improvement in the quality of life and sexuality of postmenopausal women. This effect was superior to estrogen alone and placebo. The effect of treatment with the estrogen-androgen association was evident regarding depressive humor and sexual function questions of the WHQ.

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10. de Souza, K., Vale, F. and Geber, S. – Efficacy of Tribulus terrestris for the treatment of hypoactive sexual desire disorder in postmenopausal women: a randomized, double-blinded, placebo-controlled trial. Menopause (2016) 23: 1252.

The objective of this study was to evaluate the efficacy of Tribulus terrestris for the treatment of hypoactive sexual desire disorder in postmenopausal women and evaluate its effect on the serum levels of testosterone.

We performed a prospective randomized, double-blinded, placebo-controlled study, during 18 months. A total of 45 healthy sexually active postmenopausal women reporting diminished libido were selected to participate in the study and were randomly assigned to receive 750 mg/d of T terrestris or placebo for 120 days. Randomization was performed using sealed envelopes. All participants answered the Female Sexual Function Index and the Sexual Quotient-female version questionnaires and had their serum levels of prolactin, thyroid-stimulating hormone, total testosterone, and sex hormone-binding globulin measured. A total of 36 participants completed the study, because 3 from each group were excluded due to side effects and 3 dropped out due to personal reasons. FSFI questionnaire results demonstrated an improvement in all domains in both groups (P < 0.05) except for lubrication which was improved only in the study group. QS-F results showed a significant improvement in the domains of desire (P < 0.01), arousal/lubrication (P = 0.02), pain (P = 0.02), and anorgasmia (P < 0.01) in women who used T terrestris, whereas no improvement was observed in the placebo group (P > 0.05). Moreover, free and bioavailable testosterone levels showed a significant increase in the T terrestris group (P < 0.05). Tribulus terrestris might be a safe alternative for the treatment of hypoactive sexual desire disorder in postmenopausal women, because it was effective in reducing symptoms with few side effects. Its probable mechanism of action involves an increase in the serum levels of free and bioavailable testosterone.

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11. Postigo, Lima, Yamada, dos Reis, da Silva, Aoki. – Assessment of the Effects of Tribulus Terrestris on Sexual Function of Menopausal Women.

OBJECTIVE:

The aim of this study was to study the effects of Tribulus terrestris on sexual function in menopausal women.

METHODS:

This was a prospective, randomized, double-blind, placebo-controlled clinical trial that included 60 postmenopausal women with sexual dysfunction. The women were divided into two groups, placebo group and Tribulus group, and evaluated by using the Sexual Quotient-female version (SQ-F) and Female Intervention Efficacy Index (FIEI) questionnaires.

RESULTS:

There was no significant difference between the groups in age, age at menopause, civil status, race, and religion. In the evaluation with the SQ-F questionnaire, there were significant differences between the placebo (7.6 ± 3.2) and Tribulus (10.2 ± 3.2) groups in the domains of desire and sexual interest (p ≤ 0.001), foreplay (3.3 ± 1.5 versus 4.2 ± 1.0) (p ≤ 0.01), arousal and harmonious interaction with the partner (5.7 ± 2.1 versus 7.2 ± 2.6) (p ≤ 0.01), and comfort in sexual intercourse (6.5 ± 2.4 versus 8.0 ± 1.9) (p ≤ 0.01). There was no significant difference between the placebo and Tribulus groups in the domains of orgasm and sexual satisfaction (p = 0.28). In the FIEI questionnaire, there was a significant improvement (p < 0.001) in the domains of vaginal lubrication during coitus and/or foreplay (20 versus 83.3%), sensation in the genitalia during sexual intercourse or other stimuli (16.7 versus 76.7%), sensation in the genital region (20 versus 70%), sexual intercourse and/or other sexual stimulations (13.3 versus 43.3%), and the ability to reach orgasm (20% versus 73.3%). There was no significant difference in adverse effects between the two groups.

CONCLUSIONS:

After 90 days of treatment, at the doses used, we found Tribulus terrestris to be effective in treating sexual problems among menopausal women.

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12. Saurabh Chhatre, Tanuja Nesari, Gauresh Somani, Divya Kanchan, and Sadhana Sathaye – Phytopharmacological overview of Tribulus terrestris

Tribulus terrestris (family Zygophyllaceae), commonly known as Gokshur or Gokharu or puncture vine, has been used for a long time in both the Indian and Chinese systems of medicine for treatment of various kinds of diseases. Its various parts contain a variety of chemical constituents which are medicinally important, such as flavonoids, flavonol glycosides, steroidal saponins, and alkaloids. It has diuretic, aphrodisiac, antiurolithic, immunomodulatory, antidiabetic, absorption enhancing, hypolipidemic, cardiotonic, central nervous system, hepatoprotective, antiinflammatory, analgesic, antispasmodic, anticancer, antibacterial, anthelmintic, larvicidal, and anticariogenic activities. For the last few decades or so, extensive research work has been done to prove its biological activities and the pharmacology of its extracts. The aim of this review is to create a database for further investigations of the discovered phytochemical and pharmacological properties of this plant to promote research. This will help in confirmation of its traditional use along with its valueadded utility, eventually leading to higher revenues from the plant.

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13. Dragomir Dinchev a, Bogdan Janda b, Liuba Evstatieva c, Wieslaw Oleszek b, Mohammad R. Aslani d, Ivanka Kostova – Distribution of steroidal saponins in Tribulus terrestris from different geographical regions

The steroidal saponins of Tribulus terrestris L. (Zygophyllaceae) are considered to be the factor responsible for biological activity of products derived from this plant. The activity depends on the concentration and the composition of active saponins, which in turn is influenced by the geographical origin of plant material. Samples of T. terrestris collected in Bulgaria, Greece, Serbia, Macedonia, Turkey, Georgia, Iran, Vietnam and India were analyzed by LC-ESI/MS/MS for the presence and the concentration of protodioscin (1), prototribestin (2), pseudoprotodioscin (3), dioscin (4), tribestin (5) and tribulosin (6). The flavonoid rutin (7) was also included in the comparison.

The results revealed distinct differences in the content of these compounds depending on region of sample collection, plant part studied and stage of plant development. The samples from Bulgaria, Turkey, Greece, Serbia, Macedonia, Georgia and Iran exhibited similar chemical profile and only some quantitative difference in the content of 1–7 with protodioscin (1) and prototribestin (2) as main components. The Vietnamese and Indian samples exhibit totally different chemical profile. They lack 2 and 5, while tribulosin (6) is present in high amounts. Compounds different from 1 to 7 are dominating in these 3 samples. The presented results suggested the existence of one chemotype common to the East South European and West Asian regions. Most probably, the Vietnamese and Indian samples belong to other chemotypes which are still to be studied and characterized. No clear correlation between the burrs morphology and the chemical composition of the samples has been found

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. 

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